منابع مشابه
Rapidly Proliferating Cells
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Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecular mechanism based on PARP1-Erk synergism, which may underlie this phenomenon. A stimulation induced PARP1 binding to phosphorylated Erk2 in the chr...
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A PARP1-Erk2 synergism was required to generate synaptic long-term potentiation in the CA3-CA1 hippocampal connections. This molecular mechanism was associated with the recently identified pivotal role of polyADP-ribosylation in learning. High frequency electrical stimulation of cortical and hippocampal neurons induced binding of phosphorylated Erk2 (transported into the nucleus) to the nuclear...
متن کاملIdentification of proliferating cells in hard clams.
The origin of hemocytes, the circulating "blood cell s" of bivalve molluscs, including hard clams (Mercenaria mercenaria) has not been identified ( I, 2). Proli feration of hemocytes, however, can be recognized through their increased numbers in diseased animals. ProHferating cell nuclear amigen (PC A), or cyclin, is a protein produced during the late G I and S phases of I he cell cycle (3. 4)....
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We describe a novel function of parkin, a RING protein, which is elaborately involved in mitochondrial biogenesis. Parkin was located within the mitochondrial organelle of proliferating cells. Anti-proliferative treatments released parkin from mitochondria to cytosol. Results of pharmacological treatments indicate that parkin was released from mitochondria when permeability transition pore was ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.25633